Ontology highlight
ABSTRACT:
SUBMITTER: Giannios I
PROVIDER: S-EPMC5261809 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Giannios Ioannis I Chatzantonaki Eleftheria E Georgatos Spyros S
PloS one 20170124 1
The lamin B receptor (LBR) is a multi-spanning membrane protein of the inner nuclear membrane that is often employed as a "reporter" of nuclear envelope dynamics. We show here that the diffusional mobility of full-length LBR exhibits significant regional variation along the nuclear envelope, consistent with the existence of discrete LBR microdomains and the occurrence of multiple, asymmetrically-spaced anastomoses along the nuclear envelope-endoplasmic reticulum interface. Interestingly, a commo ...[more]