Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen HD
PROVIDER: S-EPMC526199 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Nguyen Hung D HD Hall Carol K CK
Proceedings of the National Academy of Sciences of the United States of America 20041108 46
Assembly of normally soluble proteins into amyloid fibrils is a cause or associated symptom of numerous human disorders, including Alzheimer's and the prion diseases. We report molecular-level simulation of spontaneous fibril formation. Systems containing 12-96 model polyalanine peptides form fibrils at temperatures greater than a critical temperature that decreases with peptide concentration and exceeds the peptide's folding temperature, consistent with experimental findings. Formation of small ...[more]