Ontology highlight
ABSTRACT:
SUBMITTER: Smith J
PROVIDER: S-EPMC5262379 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Smith Jarrett J Calidas Deepika D Schmidt Helen H Lu Tu T Rasoloson Dominique D Seydoux Geraldine G
eLife 20161203
RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the <i>C. elegans</i> zygote, germline RNA granules, called P granules, assemble preferentially in the posterior cytoplasm. We present evidence that P granule asymmetry depends on RNA-induced phase separation of the granule scaffold MEG-3. MEG-3 is an intrinsicall ...[more]