Ontology highlight
ABSTRACT:
SUBMITTER: Chamoto K
PROVIDER: S-EPMC5262525 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chamoto Kenji K Guo Tingxi T Scally Stephen W SW Kagoya Yuki Y Anczurowski Mark M Wang Chung-Hsi CH Rahman Muhammed A MA Saso Kayoko K Butler Marcus O MO Chiu Priscilla P L PP Julien Jean-Philippe JP Hirano Naoto N
Journal of immunology (Baltimore, Md. : 1950) 20161221 3
The human invariant NK (iNK) TCR is largely composed of the invariant TCR Vα24-Jα18 chain and semivariant TCR Vβ11 chains with variable CDR3β sequences. The direct role of CDR3β in Ag recognition has been studied extensively. Although it was noted that CDR3β can interact with CDR3α, how this interaction might indirectly influence Ag recognition is not fully elucidated. We observed that the third position of Vβ11 CDR3 can encode an Arg or Ser residue as a result of somatic rearrangement. Clonotyp ...[more]