Splenectomy Does Not Improve Long-Term Outcome After Stroke.
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ABSTRACT:
SUBMITTER: Zierath D
PROVIDER: S-EPMC5263103 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Splenectomy Does Not Improve Long-Term Outcome After Stroke.
Zierath Dannielle D Shen Angela A Stults Astiana A Olmstead Theresa T Becker Kyra J KJ
Stroke 20170113 2
<h4>Background and purpose</h4>Immune responses to brain antigens after stroke contribute to poor outcome. We hypothesized that splenectomy would lessen the development of such responses and improve outcome.<h4>Methods</h4>Male Lewis rats (275-350 g) underwent 2-hour middle cerebral artery occlusion immediately after splenectomy or sham splenectomy. Animals were survived to 4 weeks (672 hrs), and immune responses to myelin basic protein determined at euthanasia. Infarct volume was determined in ...[more]
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