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High Expression of LINC01420 indicates an unfavorable prognosis and modulates cell migration and invasion in nasopharyngeal carcinoma.

ABSTRACT: Recent studies demonstrated that long non-coding RNAs (lncRNAs) deregulated in many cancer tissues including nasopharyngeal carcinoma (NPC) and had critical roles in cancer progression and metastasis. In this study, we aimed to assess a lncRNA LINC01420 expression in NPC and explore its role in NPC pathogenesis. Our research revealed that the expression level of LINC01420 in NPC tissues were higher than nasopharyngeal epithelial (NPE) tissues. Moreover, NPC patients with high LINC01420 expression level showed poor overall survival. Knockdown LINC01420 inhibited NPC cell migration and invasion in vitro. In summary, LINC01420 may play a critical role in NPC progression and may serve as a potential prognostic biomarker in NPC patients.

SUBMITTER: Yang L

PROVIDER: S-EPMC5264044 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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High Expression of LINC01420 indicates an unfavorable prognosis and modulates cell migration and invasion in nasopharyngeal carcinoma.

Yang Liting L Tang Yanyan Y He Yi Y Wang Yumin Y Lian Yu Y Xiong Fang F Shi Lei L Zhang Shanshan S Gong Zhaojian Z Zhou Yujuan Y Liao Qianjin Q Zhou Ming M Li Xiaoling X Xiong Wei W Li Yong Y Li Guiyuan G Zeng Zhaoyang Z Guo Can C

Journal of Cancer 20170101 1

Recent studies demonstrated that long non-coding RNAs (lncRNAs) deregulated in many cancer tissues including nasopharyngeal carcinoma (NPC) and had critical roles in cancer progression and metastasis. In this study, we aimed to assess a lncRNA LINC01420 expression in NPC and explore its role in NPC pathogenesis. Our research revealed that the expression level of LINC01420 in NPC tissues were higher than nasopharyngeal epithelial (NPE) tissues. Moreover, NPC patients with high LINC01420 expressio ...[more]

PMID: 28123602

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Project description:[This corrects the article DOI: 10.1371/journal.pone.0231298.].

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