Ontology highlight
ABSTRACT:
SUBMITTER: Chang WM
PROVIDER: S-EPMC5264159 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chang Wei-Min WM Lin Yuan-Feng YF Su Chia-Yi CY Peng Hsuan-Yu HY Chang Yu-Chan YC Hsiao Jenn-Ren JR Chen Chi-Long CL Chang Jang-Yang JY Shieh Yi-Shing YS Hsiao Michael M Shiah Shine-Gwo SG
Scientific reports 20170125
Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role of RUNX2/PTHLH axis, which is stimulated HNSCC cell growth. In patients, PTHLH is a poor prognosis marker. PTHLH expression lead to increasing the cell proliferation potential throu ...[more]