Infecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa.
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ABSTRACT: Introduction
Long-term natural history cohorts of HIV-1 in the absence of treatment provide the best measure of virulence by different viral subtypes.Methods
Newly HIV infected Ugandan and Zimbabwean women (N=303) were recruited and monitored for clinical, social, behavioral, immunological and viral parameters for 3 to 9.5years.Results
Ugandan and Zimbabwean women infected with HIV-1 subtype C had 2.5-fold slower rates of CD4 T-cell declines and higher frequencies of long-term non-progression than those infected with subtype A or D (GEE model, P<0.001), a difference not associated with any other clinical parameters. Relative replicative fitness and entry efficiency of HIV-1 variants directly correlated with virulence in the patients, subtype D>A>C (P<0.001, ANOVA).Discussion
HIV-1 subtype C was less virulent than either A or D in humans; the latter being the most virulent. Longer periods of asymptomatic HIV-1 subtype C could explain the continued expansion and dominance of subtype C in the global epidemic.
SUBMITTER: Venner CM
PROVIDER: S-EPMC5264310 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Infecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa.
Venner Colin M CM Nankya Immaculate I Kyeyune Fred F Demers Korey K Kwok Cynthia C Chen Pai-Lien PL Rwambuya Sandra S Munjoma Marshall M Chipato Tsungai T Byamugisha Josaphat J Van Der Pol Barbara B Mugyenyi Peter P Salata Robert A RA Morrison Charles S CS Arts Eric J EJ
EBioMedicine 20161012
<h4>Introduction</h4>Long-term natural history cohorts of HIV-1 in the absence of treatment provide the best measure of virulence by different viral subtypes.<h4>Methods</h4>Newly HIV infected Ugandan and Zimbabwean women (N=303) were recruited and monitored for clinical, social, behavioral, immunological and viral parameters for 3 to 9.5years.<h4>Results</h4>Ugandan and Zimbabwean women infected with HIV-1 subtype C had 2.5-fold slower rates of CD4 T-cell declines and higher frequencies of long ...[more]
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