Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.
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ABSTRACT:
SUBMITTER: Joehanes R
PROVIDER: S-EPMC5264466 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.
Joehanes Roby R Zhang Xiaoling X Huan Tianxiao T Yao Chen C Ying Sai-Xia SX Nguyen Quang Tri QT Demirkale Cumhur Yusuf CY Feolo Michael L ML Sharopova Nataliya R NR Sturcke Anne A Schäffer Alejandro A AA Heard-Costa Nancy N Chen Han H Liu Po-Ching PC Wang Richard R Woodhouse Kimberly A KA Tanriverdi Kahraman K Freedman Jane E JE Raghavachari Nalini N Dupuis Josée J Johnson Andrew D AD O'Donnell Christopher J CJ Levy Daniel D Munson Peter J PJ
Genome biology 20170125 1
<h4>Background</h4>Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as expression quantitative trait loci (eQTLs), may improve understanding of the functional role of phenotype-associated SNPs in genome-wide association studies (GWAS). The small sample sizes of some previous eQTL studies have limited their statistical power. We conducted an eQTL investigation of microarray-based gene and exon expression levels in whole blood in a cohort of 52 ...[more]
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