Engineering Escherichia coli for light-activated cytolysis of mammalian cells.
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ABSTRACT:
SUBMITTER: Magaraci MS
PROVIDER: S-EPMC5264543 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Engineering Escherichia coli for light-activated cytolysis of mammalian cells.
Magaraci Michael S MS Veerakumar Avin A Qiao Peter P Amurthur Ashwin A Lee Justin Y JY Miller Jordan S JS Goulian Mark M Sarkar Casim A CA
ACS synthetic biology 20140114 12
By delivering payloads in response to specific exogenous stimuli, smart bacterial therapeutics have the potential to overcome many limitations of conventional therapies, including poor targeting specificity and dosage control in current cancer treatments. Although not yet explored as a trigger for bacterial drug delivery, light is an ideal induction mechanism because it offers fine spatiotemporal control and is easily and safely administered. Using recent advances in optogenetics, we have engine ...[more]
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