Ontology highlight
ABSTRACT:
SUBMITTER: Winchenbach J
PROVIDER: S-EPMC5265728 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Winchenbach Jan J Düking Tim T Berghoff Stefan A SA Stumpf Sina K SK Hülsmann Swen S Nave Klaus-Armin KA Saher Gesine G
F1000Research 20161230
<i>Background:</i> Studying astrocytes in higher brain functions has been hampered by the lack of genetic tools for the efficient expression of inducible Cre recombinase throughout the CNS, including the neocortex. <i>Methods:</i> Therefore, we generated BAC transgenic mice, in which CreERT2 is expressed under control of the <i>Aldh1l1</i> regulatory region. <i>Results:</i> When crossbred to Cre reporter mice, adult Aldh1l1-CreERT2 mice show efficient gene targeting in astrocytes. No such Cre-me ...[more]