Ontology highlight
ABSTRACT:
SUBMITTER: Perera RT
PROVIDER: S-EPMC5266612 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nanotechnology 20150128 7
The carcinogenic precursor benzo[a]pyrene (BP), a polycyclic aromatic hydrocarbon, is released into the environment through the incomplete combustion of hydrocarbons. Metabolism of BP in the human body yields a potent alkylating agent (benzo[a]pyrene diol epoxide, BPDE) that reacts with guanine (G) in DNA to form an adduct implicated in cancer initiation. We report that the α-hemolysin (αHL) nanopore platform can be used to detect a BPDE adduct to G in synthetic oligodeoxynucleotides. Translocat ...[more]