Genome-wide methylation data mirror ancestry information.

ABSTRACT:

Background

Genetic data are known to harbor information about human demographics, and genotyping data are commonly used for capturing ancestry information by leveraging genome-wide differences between populations. In contrast, it is not clear to what extent population structure is captured by whole-genome DNA methylation data.

Results

We demonstrate, using three large-cohort 450K methylation array data sets, that ancestry information signal is mirrored in genome-wide DNA methylation data and that it can be further isolated more effectively by leveraging the correlation structure of CpGs with cis-located SNPs. Based on these insights, we propose a method, EPISTRUCTURE, for the inference of ancestry from methylation data, without the need for genotype data.

Conclusio

SUBMITTER: Rahmani E 

PROVIDER: S-EPMC5267476 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature