Ontology highlight
ABSTRACT:
SUBMITTER: Kjaerby C
PROVIDER: S-EPMC5268074 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kjaerby Celia C Athilingam Jegath J Robinson Sarah E SE Iafrati Jillian J Sohal Vikaas S VS
Cell reports 20161201 11
Both medial prefrontal cortex (mPFC) and serotonin play key roles in anxiety; however, specific mechanisms through which serotonin might act on the mPFC to modulate anxiety-related behavior remain unknown. Here, we use a combination of optogenetics and synaptic physiology to show that serotonin acts presynaptically via 5-HT1B receptors to selectively suppress inputs from the contralateral mPFC and ventral hippocampus (vHPC), while sparing those from mediodorsal thalamus. To elucidate how these a ...[more]