Ontology highlight
ABSTRACT:
SUBMITTER: Khoshkhoo S
PROVIDER: S-EPMC5268075 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Khoshkhoo Sattar S Vogt Daniel D Sohal Vikaas S VS
Neuron 20161229 2
GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we describe a mouse model for optogenetic seizure induction. Combining this with calcium imaging, we find that seizure onset rapidly recruits parvalbumin (PV), somatostatin (SOM), and va ...[more]