Ontology highlight
ABSTRACT:
SUBMITTER: Iwamoto K
PROVIDER: S-EPMC5268383 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Iwamoto Kazunori K Uehara Yutaka Y Inoue Yukie Y Taguchi Kyoko K Muraoka Daisuke D Ogo Naohisa N Matsuno Kenji K Asai Akira A
PloS one 20170126 1
Bendamustine (BENDA), which bears the bis(2-chloroethyl)amino moiety, is an alkylating agent that stops the growth of cancer cells by binding to DNA and interfering with its replication. However, the mechanism of action underlying its excellent clinical efficacy remains unclear. In this work, we report that BENDA inhibits signal transducer and activator of transcription 3 (STAT3). In an AlphaScreen-based biochemical assay using recombinant human STAT3, binding of STAT3-Src homology 2 (SH2) to th ...[more]