Dataset Information

Cross calibration of two dual-energy X-ray densitometers and comparison of visceral adipose tissue measurements by iDXA and MRI.

ABSTRACT:

Objective

Compare total percentage body fat (pfat) measurements between two densitometers and visceral adipose tissue (VAT) estimates between iDXA and magnetic resonance imaging (MRI) from the same defined abdominal region.

Methods

Participants [N = 93 (50 men, 43 women), BMI: 19.1-57.6 kg/m² ] underwent dual-energy X-ray absorptiometry (DXA) scans on two DXA systems (GE Healthcare Lunar iDXA and Lunar Prodigy), and a subgroup underwent abdominal MRI imaging for quantification of VAT.

Results

Pfat correlated strongly between both machines (r² ?=?0.98, P?2 for regression of MRI on iDXA VAT values was 0.948. Bland-Altman bias was +104.1 cm³ with 95% limits of agreement of -681.9 to 890.0 cm³ . For both DXA methods, and iDXA versus MRI determined VAT, comparison using rank regression demonstrated no order bias.

Conclusions

The total pfat measured by both machines was strongly and linearly associated, allowing for conversion (equations are provided) of iDXA for assessment of longitudinal body fat changes. Despite a bias of abdominal VAT measures of iDXA versus MRI, the high rank correlation makes iDXA a good alternative to the more complicated and time-consuming MRI for use in larger cross-sectional and longitudinal studies.

SUBMITTER: Reinhardt M

PROVIDER: S-EPMC5269467 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Publications

Cross calibration of two dual-energy X-ray densitometers and comparison of visceral adipose tissue measurements by iDXA and MRI.

Reinhardt Martin M Piaggi Paolo P DeMers Barbara B Trinidad Cathy C Krakoff Jonathan J

Obesity (Silver Spring, Md.) 20161221 2

<h4>Objective</h4>Compare total percentage body fat (pfat) measurements between two densitometers and visceral adipose tissue (VAT) estimates between iDXA and magnetic resonance imaging (MRI) from the same defined abdominal region.<h4>Methods</h4>Participants [N = 93 (50 men, 43 women), BMI: 19.1-57.6 kg/m<sup>2</sup> ] underwent dual-energy X-ray absorptiometry (DXA) scans on two DXA systems (GE Healthcare Lunar iDXA and Lunar Prodigy), and a subgroup underwent abdominal MRI imaging for quantif ...[more]

PMID: 28000375

Similar Datasets

Project description:Background/objectivesIndividuals with HIV are susceptible to visceral fat accumulation, which confers an increased risk of cardiometabolic disease. Advanced software to ascertain visceral fat content from dual-energy X-ray absorptiometry (DXA) has not been validated among this population. We sought to compare DXA with computed tomography (CT) in the measurement of visceral fat cross-sectional area (VAT) in HIV and non-HIV using Bland-Altman analyses.Subjects/methodsData were combined from five previously conducted studies of individuals with HIV (n = 313) and controls without HIV (n = 144) in which paired DXA and CT scans were available. In cross-sectional analyses, DXA-VAT was compared with CT-VAT among participants with and without HIV. In longitudinal analyses, changes in VAT over time were compared between DXA and CT among participants with and without HIV receiving no intervention over 12 months and among individuals with HIV receiving tesamorelin-a medication known to reduce VAT-over 6 months.ResultsIn HIV, DXA underestimated VAT compared with CT among individuals with increased visceral adiposity. The measurement bias was -9 ± 47 cm2 overall, but became progressively larger with greater VAT (P < 0.0001), e.g., -61 ± 58 cm2 among those with VAT ≥ 200 cm2. Sex-stratified analyses revealed that the relationship between VAT and measurement bias was especially pronounced in men (P < 0.0001). Longitudinally, DXA underestimated changes in VAT, particularly among those at the extremes of VAT gain or loss (P < 0.0001). In contrast to the cross-sectional findings, the tendency for DXA to underestimate longitudinal changes in VAT was evident in both men and women. Analogous findings were seen among controls in cross-sectional and longitudinal analyses.ConclusionsDXA underestimated VAT relative to CT in men with and without HIV, who had increased visceral adiposity. DXA also underestimated changes in VAT over time in men and women, irrespective of HIV status. DXA-VAT should be used with caution among both HIV and non-HIV-infected populations.

Dataset Information

Cross calibration of two dual-energy X-ray densitometers and comparison of visceral adipose tissue measurements by iDXA and MRI.

Objective

Methods

Results

Conclusions

Publications

Cross calibration of two dual-energy X-ray densitometers and comparison of visceral adipose tissue measurements by iDXA and MRI.

Similar Datasets

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