Ontology highlight
ABSTRACT:
SUBMITTER: Calabrese GM
PROVIDER: S-EPMC5269473 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Calabrese Gina M GM Mesner Larry D LD Stains Joseph P JP Tommasini Steven M SM Horowitz Mark C MC Rosen Clifford J CJ Farber Charles R CR
Cell systems 20161117 1
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. Genome-wide association studies (GWAS) for BMD have identified dozens of associations; yet, the genes responsible for most associations remain elusive. Here, we used a bone co-expression network to predict causal genes at BMD GWAS loci based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed. By mapping genes implicated by BMD GWAS ...[more]