Ontology highlight
ABSTRACT:
SUBMITTER: Dulken BW
PROVIDER: S-EPMC5269583 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cell reports 20170101 3
Neural stem cells (NSCs) in the adult mammalian brain serve as a reservoir for the generation of new neurons, oligodendrocytes, and astrocytes. Here, we use single-cell RNA sequencing to characterize adult NSC populations and examine the molecular identities and heterogeneity of in vivo NSC populations. We find that cells in the NSC lineage exist on a continuum through the processes of activation and differentiation. Interestingly, rare intermediate states with distinct molecular profiles can be ...[more]