Combining omics data to identify genes associated with allergic rhinitis.
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ABSTRACT:
SUBMITTER: Morin A
PROVIDER: S-EPMC5270349 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Combining omics data to identify genes associated with allergic rhinitis.
Morin Andréanne A Laviolette Michel M Pastinen Tomi T Boulet Louis-Philippe LP Laprise Catherine C
Clinical epigenetics 20170118
Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association studies and linked marginally significant CpGs located in genes or its promoter and SNPs located 1 Mb from the CpGs, by identifying <i>cis</i> methylation quantitative trait loci (mQTL). This approach relies on functional cellular aspects rather than stringent statistical correction. We were a ...[more]
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