Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia.
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ABSTRACT:
SUBMITTER: Winerdal M
PROVIDER: S-EPMC5271335 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia.
Winerdal Max M Urmaliya Vijay V Winerdal Malin E ME Fredholm Bertil B BB Winqvist Ola O Ådén Ulrika U
PloS one 20170127 1
In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neon ...[more]
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