Ontology highlight
ABSTRACT:
SUBMITTER: Henley AB
PROVIDER: S-EPMC5271386 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Henley Aine Brigette AB Yang Ling L Chuang Kun-Lin KL Sahuri-Arisoylu Meliz M Wu Li-Hong LH Bligh S W Annie SW Bell Jimmy David JD
PloS one 20170127 1
Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed t ...[more]