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Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'.


ABSTRACT: Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells.

SUBMITTER: Henley AB 

PROVIDER: S-EPMC5271386 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'.

Henley Aine Brigette AB   Yang Ling L   Chuang Kun-Lin KL   Sahuri-Arisoylu Meliz M   Wu Li-Hong LH   Bligh S W Annie SW   Bell Jimmy David JD  

PloS one 20170127 1


Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed t  ...[more]

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