Ontology highlight
ABSTRACT:
SUBMITTER: Cui Y
PROVIDER: S-EPMC5271409 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cui Ye Y Yu Huansha H Zheng Xin X Peng Rui R Wang Qiang Q Zhou Yi Y Wang Rui R Wang Jiehua J Qu Bo B Shen Nan N Guo Qiang Q Liu Xing X Wang Chen C
PLoS pathogens 20170117 1
Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease 7 (SENP7) interacted with and potentiated cGAS activation. The small ubiquitin-like modifier (SUMO) was conjugated onto the lysine residues 335, 372 and 382 of cGAS, which suppress ...[more]