Ontology highlight
ABSTRACT:
SUBMITTER: Russo J
PROVIDER: S-EPMC5271678 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Russo Joseph J Lee Jerome E JE López Carolina M CM Anderson John J Nguyen Thuy-Mi P TP Heck Adam M AM Wilusz Jeffrey J Wilusz Carol J CJ
PloS one 20170127 1
We previously identified several mRNAs encoding components of the secretory pathway, including signal recognition particle (SRP) subunit mRNAs, among transcripts associated with the RNA-binding protein CELF1. Through immunoprecipitation of RNAs crosslinked to CELF1 in myoblasts and in vitro binding assays using recombinant CELF1, we now provide evidence that CELF1 directly binds the mRNAs encoding each of the subunits of the SRP. Furthermore, we determined the half-lives of the Srp transcripts i ...[more]