Ontology highlight
ABSTRACT:
SUBMITTER: van der Mark VA
PROVIDER: S-EPMC5272906 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
van der Mark Vincent A VA Ghiboub Mohammed M Marsman Casper C Zhao Jing J van Dijk Remco R Hiralall Johan K JK Ho-Mok Kam S KS Castricum Zoë Z de Jonge Wouter J WJ Oude Elferink Ronald P J RP Paulusma Coen C CC
Cellular and molecular life sciences : CMLS 20160914 4
P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time, that lipid flippases are essential to dampen the inflammatory response and to mediate the endotoxin-induced endocytic retrieval of Toll-like receptor 4 (TLR4) in human macrophages. Depletion of CDC50A, the β-subunit that is crucial for the activity of multiple P4-ATPases, resulted in endotoxin ...[more]