Ontology highlight
ABSTRACT:
SUBMITTER: Jastrzebska B
PROVIDER: S-EPMC5274527 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Jastrzebska Beata B Comar William D WD Kaliszewski Megan J MJ Skinner Kevin C KC Torcasio Morgan H MH Esway Anthony S AS Jin Hui H Palczewski Krzysztof K Smith Adam W AW
Biochemistry 20161129 1
G protein-coupled receptors (GPCRs) detect a wide variety of physical and chemical signals and transmit that information across the cellular plasma membrane. Dimerization is a proposed modulator of GPCR signaling, but the structure and stability of class A GPCR dimerization have been difficult to establish. Here we investigated the dimerization affinity and binding interface of human cone opsins, which initiate and sustain daytime color vision. Using a time-resolved fluorescence approach, we fou ...[more]