Ontology highlight
ABSTRACT:
SUBMITTER: Premchandar A
PROVIDER: S-EPMC5275743 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Premchandar Aiswarya A Kupniewska Anna A Bonna Arkadiusz A Faure Grazyna G Fraczyk Tomasz T Roldan Ariel A Hoffmann Brice B Faria da Cunha Mélanie M Herrmann Harald H Lukacs Gergely L GL Edelman Aleksander A Dadlez Michał M
Protein science : a publication of the Protein Society 20170201 2
The intermediate filament protein keratin 8 (K8) interacts with the nucleotide-binding domain 1 (NBD1) of the cystic fibrosis (CF) transmembrane regulator (CFTR) with phenylalanine 508 deletion (ΔF508), and this interaction hampers the biogenesis of functional ΔF508-CFTR and its insertion into the plasma membrane. Interruption of this interaction may constitute a new therapeutic target for CF patients bearing the ΔF508 mutation. Here, we aimed to determine the binding surface between these two p ...[more]