A Novel Human Tissue-Engineered 3-D Functional Vascularized Cardiac Muscle Construct.

ABSTRACT: Organ tissue engineering, including cardiovascular tissues, has been an area of intense investigation. The major challenge to these approaches has been the inability to vascularize and perfuse the in vitro engineered tissue constructs. Attempts to provide oxygen and nutrients to the cells contained in the biomaterial constructs have had varying degrees of success. The aim of this current study is to develop a three-dimensional (3-D) model of vascularized cardiac tissue to examine the concurrent temporal and spatial regulation of cardiomyogenesis in the context of postnatal de novo vasculogenesis during stem cell cardiac regeneration. In order to achieve the above aim, we have developed an in vitro 3-D functional vascularized cardiac muscle construct using human induced

SUBMITTER: Valarmathi MT 

PROVIDER: S-EPMC5276820 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature