Ontology highlight
ABSTRACT:
SUBMITTER: Akatsu Y
PROVIDER: S-EPMC5276835 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Akatsu Yuichi Y Yoshimatsu Yasuhiro Y Tomizawa Taishi T Takahashi Kazuki K Katsura Akihiro A Miyazono Kohei K Watabe Tetsuro T
Cancer science 20170101 1
Clinical development of anti-angiogenic agents has been a major landmark in cancer therapy for several types of cancers. Signals mediated by both vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP)-9 and 10 have been implicated in tumor angiogenesis. However, previous studies have shown that targeting the individual signals was not sufficiently effective in retarding tumor growth in certain preclinical and clinical conditions. In the present study, we developed a novel ...[more]