Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression.
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ABSTRACT:
SUBMITTER: Ebata T
PROVIDER: S-EPMC5278210 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression.
Ebata Takahiro T Mitsui Yasumasa Y Sugimoto Wataru W Maeda Miho M Araki Keigo K Machiyama Hiroaki H Harada Ichiro I Sawada Yasuhiro Y Fujita Hideaki H Hirata Hiroaki H Kawauchi Keiko K
BioMed research international 20170116
The physical properties of the extracellular matrix (ECM), such as stiffness, are involved in the determination of the characteristics of cancer cells, including chemotherapy sensitivity. Resistance to chemotherapy is often linked to dysfunction of tumor suppressor p53; however, it remains elusive whether the ECM microenvironment interferes with p53 activation in cancer cells. Here, we show that, in MCF-7 breast cancer cells, extracellular stiffness influences p53 activation induced by the antit ...[more]
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