Ontology highlight
ABSTRACT:
SUBMITTER: Saxena K
PROVIDER: S-EPMC5278484 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Saxena Kapil K Simon Lukas M LM Zeng Xi-Lei XL Blutt Sarah E SE Crawford Sue E SE Sastri Narayan P NP Karandikar Umesh C UC Ajami Nadim J NJ Zachos Nicholas C NC Kovbasnjuk Olga O Donowitz Mark M Conner Margaret E ME Shaw Chad A CA Estes Mary K MK
Proceedings of the National Academy of Sciences of the United States of America 20170109 4
The intestinal epithelium can limit enteric pathogens by producing antiviral cytokines, such as IFNs. Type I IFN (IFN-α/β) and type III IFN (IFN-λ) function at the epithelial level, and their respective efficacies depend on the specific pathogen and site of infection. However, the roles of type I and type III IFN in restricting human enteric viruses are poorly characterized as a result of the difficulties in cultivating these viruses in vitro and directly obtaining control and infected small int ...[more]