Ontology highlight
ABSTRACT:
SUBMITTER: Kvainickas A
PROVIDER: S-EPMC5278674 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kvainickas Arunas A Orgaz Ana Jimenez AJ Nägele Heike H Diedrich Britta B Heesom Kate J KJ Dengjel Jörn J Cullen Peter J PJ Steinberg Florian F
Journal of cell science 20161201 2
Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's association with the WASH complex and also with the uncharacterized protein ankyrin-repeat-domain-containing protein 50 (ANKRD50). Here, we firmly establish ANKRD50 as a new and essential component of the SNX27-retromer-WASH super comple ...[more]