Unknown

Dataset Information

0

Pentostatin, cyclophosphamide and rituximab for previously untreated advanced stage, low-grade B-cell lymphomas.


ABSTRACT: We conducted a prospective phase II trial of pentostatin, cyclophosphamide and rituximab as initial therapy for patients with previously untreated advanced stage low-grade or indolent B-cell lymphomas (iNHLs). Of 83 evaluable patients, 91·6% attained an overall response and 86·8% a complete or unconfirmed complete response. The 3-year progression-free survival (PFS) and overall survival rates were 73% and 93%, respectively. The 3-year PFS rate was significantly different for different diagnoses (P = 0·01): 83% [95% confidence interval (CI): 0·72, 0·96] for follicular lymphomas, 73% (95% CI: 0·54, 1·0) for marginal zone lymphomas and 61% (95% CI: 0·46, 0·81) for small lymphocytic lymphomas. The most common adverse events were haematological. Of 509 cycles of chemotherapy administered, grade 3 or 4 neutropenia was reported in 68 cycles (13% of cycles administered) and most frequently occurred during cycles 4-6. This is the first report demonstrating the effectiveness of pentostatin, cyclophosphamide and rituximab in patients with previously untreated iNHLs, including those over 60 years of age.

SUBMITTER: Samaniego F 

PROVIDER: S-EPMC5278955 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications


We conducted a prospective phase II trial of pentostatin, cyclophosphamide and rituximab as initial therapy for patients with previously untreated advanced stage low-grade or indolent B-cell lymphomas (iNHLs). Of 83 evaluable patients, 91·6% attained an overall response and 86·8% a complete or unconfirmed complete response. The 3-year progression-free survival (PFS) and overall survival rates were 73% and 93%, respectively. The 3-year PFS rate was significantly different for different diagnoses  ...[more]

Similar Datasets

| S-EPMC3390263 | biostudies-literature
| S-EPMC3204728 | biostudies-literature
| S-EPMC9631712 | biostudies-literature
| S-EPMC10476837 | biostudies-literature
2011-03-04 | GSE27659 | GEO
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
| S-EPMC5123195 | biostudies-literature
| S-EPMC3266999 | biostudies-literature
| S-EPMC8536603 | biostudies-literature