Ontology highlight
ABSTRACT:
SUBMITTER: Chinen M
PROVIDER: S-EPMC5279065 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chinen Madoka M Lei Elissa P EP
Biochemical and biophysical research communications 20170110 3
Argonaute (AGO) proteins play a central role in the RNA interference (RNAi) pathway, which is a cytoplasmic mechanism important for post-transcriptional regulation of gene expression. In Drosophila, AGO2 also functions in the nucleus to regulate chromatin insulator activity and transcription. Although there are a number of studies focused on AGO2 function, the regulation of AGO2 turnover is not well understood. We found that mutation of T1149 or R1158 in the conserved PIWI domain causes AGO2 pro ...[more]