Ontology highlight
ABSTRACT:
SUBMITTER: Brier MR
PROVIDER: S-EPMC5279747 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Brier Matthew R MR McCarthy John E JE Benzinger Tammie L S TLS Stern Ari A Su Yi Y Friedrichsen Karl A KA Morris John C JC Ances Beau M BM Vlassenko Andrei G AG
Neurobiology of aging 20151031
Amyloid-beta plaques are a hallmark of Alzheimer's disease (AD) that can be assessed by amyloid imaging (e.g., Pittsburgh B compound [PiB]) and summarized as a scalar value. Summary values may have clinical utility but are an average over many regions of interest, potentially obscuring important topography. This study investigates the longitudinal evolution of amyloid topographies in cognitively normal older adults who had normal (N = 131) or abnormal (N = 26) PiB scans at baseline. At 3 years f ...[more]