Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination.

ABSTRACT: Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of exercise may vary with its regime. Less is known about how distinct exercise paradigms may differentially affect the learning behavior. Here we found that, chronic moderate treadmill running led to an increase of cell proliferation, survival, neuronal differentiation, and migration. In contrast, intense running only promoted neuronal differentiation and migration, which was accompanied with lower expressions of vascular endothelial growth factor, brain-derived neurotrophic factor, insulin-like growth factor 1, and erythropoietin. In addition, t

SUBMITTER: So JH 

PROVIDER: S-EPMC5281566 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature