Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study.

ABSTRACT: The mechanisms involved in the chronic hepatitis C progression are incompletely understood. The aim was to analyze the association between 2'5'oligoadenylate synthetase 1,2 and 3 (OAS1-3) and myxovirus resistance proteins 1 (Mx1) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. We performed a cross-sectional study in 219 patients that underwent a liver biopsy. DNA genotyping for Mx1 (rs469390), OAS1 (rs2285934), OAS2 (rs1293762) and OAS3 (rs2010604) was performed by using GoldenGate assay. The outcome variables ion liver biopsy were: (i) significant fibrosis (F???2); (ii) moderate activity grade (A???2). Additive model of inheritance for genetic association test was used. The likelihood of having significant fibrosis (F???2) was lower in patients carrying OAS2 rs1293762 A allele [adjusted odds ratio (aOR)?=?0.51; p?=?0.040]. Besides, the likelihood of having moderate activity grade (A???2) was higher in patients carrying Mx1 rs464397 C allele (aOR?=?1.63; p?=?0.028) and Mx1 rs469390 G allele (aOR?=?1.97; p?=?0.005), while it was lower in patients carrying OAS1 rs2285934 A allele (aOR?=?0.64; p?=?0.039) and OAS2 rs1293762 A allele (aOR?=?0.41; p?=?0.009). In conclusion, Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis.

SUBMITTER: Garcia-Alvarez M 

PROVIDER: S-EPMC5282518 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature