Unknown

Dataset Information

0

Single-Cell Analysis in Cancer Genomics.


ABSTRACT: Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment. In this paper we review the recent single-cell technological and computational advances at the genomic, transcriptomic, and proteomic levels, and discuss their applications in cancer research.

SUBMITTER: Saadatpour A 

PROVIDER: S-EPMC5282606 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Single-Cell Analysis in Cancer Genomics.

Saadatpour Assieh A   Lai Shujing S   Guo Guoji G   Yuan Guo-Cheng GC  

Trends in genetics : TIG 20151001 10


Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment. In this paper we review the recent single-cell technological and computational advances at the genomic, transcriptom  ...[more]

Similar Datasets

| S-EPMC5901877 | biostudies-other
| S-EPMC6443043 | biostudies-literature
| S-EPMC7788095 | biostudies-literature
| S-EPMC5771881 | biostudies-literature
| S-EPMC6337828 | biostudies-literature
| S-EPMC8833749 | biostudies-literature
| S-EPMC5716224 | biostudies-literature
| S-EPMC6065048 | biostudies-literature
| S-EPMC10434946 | biostudies-literature
| S-EPMC10515959 | biostudies-literature