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Single-Cell Analysis in Cancer Genomics.

ABSTRACT: Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment. In this paper we review the recent single-cell technological and computational advances at the genomic, transcriptomic, and proteomic levels, and discuss their applications in cancer research.

SUBMITTER: Saadatpour A

PROVIDER: S-EPMC5282606 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Single-Cell Analysis in Cancer Genomics.

Saadatpour Assieh A Lai Shujing S Guo Guoji G Yuan Guo-Cheng GC

Trends in genetics : TIG 20151001 10

Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment. In this paper we review the recent single-cell technological and computational advances at the genomic, transcriptom ...[more]

PMID: 26450340

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