Single-Cell Analysis in Cancer Genomics.
Ontology highlight
ABSTRACT:
SUBMITTER: Saadatpour A
PROVIDER: S-EPMC5282606 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Single-Cell Analysis in Cancer Genomics.
Saadatpour Assieh A Lai Shujing S Guo Guoji G Yuan Guo-Cheng GC
Trends in genetics : TIG 20151001 10
Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, identify rare cell types, measure mutation rates, and, ultimately, guide diagnosis and treatment. In this paper we review the recent single-cell technological and computational advances at the genomic, transcriptom ...[more]
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