Ontology highlight
ABSTRACT:
SUBMITTER: Gulerez I
PROVIDER: S-EPMC5283600 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Gulerez Irina I Funato Yosuke Y Wu Howie H Yang Meng M Kozlov Guennadi G Miki Hiroaki H Gehring Kalle K
EMBO reports 20161117 12
PRLs (phosphatases of regenerating liver) are frequently overexpressed in human cancers and are prognostic markers of poor survival. Despite their potential as therapeutic targets, their mechanism of action is not understood in part due to their weak enzymatic activity. Previous studies revealed that PRLs interact with CNNM ion transporters and prevent CNNM4-dependent Mg<sup>2+</sup> transport, which is important for energy metabolism and tumor progression. Here, we report that PRL-CNNM complex ...[more]