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Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus.


ABSTRACT: A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myeloma growth and simultaneously eradicating thrombus complication.

SUBMITTER: Hu Q 

PROVIDER: S-EPMC5283718 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus.

Hu Quanyin Q   Qian Chenggen C   Sun Wujin W   Wang Jinqiang J   Chen Zhaowei Z   Bomba Hunter N HN   Xin Hongliang H   Shen Qundong Q   Gu Zhen Z  

Advanced materials (Deerfield Beach, Fla.) 20160914 43


A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myeloma growth and simultaneously eradicating thrombus complication. ...[more]

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