Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation.
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ABSTRACT:
SUBMITTER: Struts AV
PROVIDER: S-EPMC5283944 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation.
Struts Andrey V AV Salgado Gilmar F J GF Martínez-Mayorga Karina K Brown Michael F MF
Nature structural & molecular biology 20110130 3
X-ray and magnetic resonance approaches, though central to studies of G protein-coupled receptor (GPCR)-mediated signaling, cannot address GPCR protein dynamics or plasticity. Here we show that solid-state (2)H NMR relaxation elucidates picosecond-to-nanosecond-timescale motions of the retinal ligand that influence larger-scale functional dynamics of rhodopsin in membranes. We propose a multiscale activation mechanism whereby retinal initiates collective helix fluctuations in the meta I-meta II ...[more]
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