Ontology highlight
ABSTRACT:
SUBMITTER: Mesquita FS
PROVIDER: S-EPMC5286360 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Mesquita Francisco Sarmento FS Brito Cláudia C Mazon Moya Maria J MJ Pinheiro Jorge Campos JC Mostowy Serge S Cabanes Didier D Sousa Sandra S
EMBO reports 20161230 2
During infection, plasma membrane (PM) blebs protect host cells against bacterial pore-forming toxins (PFTs), but were also proposed to promote pathogen dissemination. However, the details and impact of blebbing regulation during infection remained unclear. Here, we identify the endoplasmic reticulum chaperone Gp96 as a novel regulator of PFT-induced blebbing. Gp96 interacts with non-muscle myosin heavy chain IIA (NMHCIIA) and controls its activity and remodelling, which is required for appropri ...[more]