Ontology highlight
ABSTRACT:
SUBMITTER: Azad A
PROVIDER: S-EPMC5286375 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Azad Abul A Yin Lim Su S D'Costa Zenobia Z Jones Keaton K Diana Angela A Sansom Owen J OJ Kruger Philipp P Liu Stanley S McKenna W Gillies WG Dushek Omer O Muschel Ruth J RJ Fokas Emmanouil E
EMBO molecular medicine 20170201 2
Pancreatic ductal adenocarcinoma (PDAC) is considered a non-immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of KPC and Pan02 murine PDAC cells with RT and gemcitabine upregulated PD-L1 expression in a JAK/Stat1-dependent manner. In vitro, PD-L1 inhibition did not alter radio- and chemosensitivity. In vivo, addition of anti-PD-L1 to high (12, 5 × 3, 20 Gy) but not low (6, ...[more]