Ontology highlight
ABSTRACT:
SUBMITTER: Reiterer V
PROVIDER: S-EPMC5286380 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Reiterer Veronika V Figueras-Puig Cristina C Le Guerroue Francois F Confalonieri Stefano S Vecchi Manuela M Jalapothu Dasaradha D Kanse Sandip M SM Deshaies Raymond J RJ Di Fiore Pier Paolo PP Behrends Christian C Farhan Hesso H
The EMBO journal 20161222 3
The F-box protein FBXW7 is the substrate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-suppressor protein that is altered in several human malignancies. Loss of function of FBXW7 results in the stabilization of numerous proteins that orchestrate cell proliferation and survival. Little is known about proteins that directly regulate the function of this protein. In the current work, we have mapped the interactome of the enigmatic pseudophosphatase STYX We reasoned that a catalyti ...[more]