Ontology highlight
ABSTRACT:
SUBMITTER: Ishida H
PROVIDER: S-EPMC5286426 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20170201
L-plastin is a calcium-regulated actin-bundling protein that is expressed in cells of hematopoietic origin and in most metastatic cancer cells. These cell types are mobile and require the constant remodeling of their actin cytoskeleton, where L-plastin bundles filamentous actin. The calcium-dependent regulation of the actin-bundling activity of L-plastin is not well understood. We have used NMR spectroscopy to determine the solution structure of the EF-hand calcium-sensor headpiece domain. Unexp ...[more]