Ontology highlight
ABSTRACT:
SUBMITTER: Di Giglio MG
PROVIDER: S-EPMC5286520 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Di Giglio Maria Giulia MG Muttenthaler Markus M Harpsøe Kasper K Liutkeviciute Zita Z Keov Peter P Eder Thomas T Rattei Thomas T Arrowsmith Sarah S Wray Susan S Marek Ales A Elbert Tomas T Alewood Paul F PF Gloriam David E DE Gruber Christian W CW
Scientific reports 20170201
Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old oxytocin/vasopressin signalling system. We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius niger), identified and c ...[more]