Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
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ABSTRACT:
SUBMITTER: Igartua C
PROVIDER: S-EPMC5286564 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
Igartua Catherine C Davenport Emily R ER Gilad Yoav Y Nicolae Dan L DL Pinto Jayant J Ober Carole C
Microbiome 20170201 1
<h4>Background</h4>The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder population of European decent.<h4>Results</h4>We estimated the relative abundances (RAs) of genus level bacteria from 16S rRNA gene sequences and examined associations with 1 ...[more]
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