Unknown

Dataset Information

0

Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.

ABSTRACT: The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder population of European decent.We estimated the relative abundances (RAs) of genus level bacteria from 16S rRNA gene sequences and examined associations with 148,653 genetic variants (linkage disequilibrium [LD] r 2?

SUBMITTER: Igartua C 

PROVIDER: S-EPMC5286564 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.

Igartua Catherine C   Davenport Emily R ER   Gilad Yoav Y   Nicolae Dan L DL   Pinto Jayant J   Ober Carole C  

Microbiome 20170201 1

<h4>Background</h4>The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder population of European decent.<h4>Results</h4>We estimated the relative abundances (RAs) of genus level bacteria from 16S rRNA gene sequences and examined associations with 1  ...[more]

Similar Datasets

Unknown Host genetic variation and its microbiome interactions within the Human Microbiome Project.
| S-EPMC5789541 | biostudies-literature
Unknown Host genetic variation influences gene expression response to rhinovirus infection.
| S-EPMC4395341 | biostudies-literature
Unknown Host genetic variation impacts microbiome composition across human body sites.
| S-EPMC4570153 | biostudies-literature
Transcriptomics Natural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways
2016-02-16 | E-GEOD-77905 | biostudies-arrayexpress
Transcriptomics Natural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways
2016-02-16 | GSE77905 | GEO
Unknown Rare genetic variation in mitochondrial pathways influences the risk for Parkinson's disease.
| S-EPMC6282592 | biostudies-literature
Unknown Natural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways.
| S-EPMC4795773 | biostudies-literature
Unknown Circadian Host-Microbiome Interactions in Immunity.
| S-EPMC7456996 | biostudies-literature
Unknown Highly Reproducible 16S Sequencing Facilitates Measurement of Host Genetic Influences on the Stickleback Gut Microbiome.
| S-EPMC6697441 | biostudies-literature
Unknown HOMINID: a framework for identifying associations between host genetic variation and microbiome composition.
| S-EPMC5740987 | biostudies-literature