Ontology highlight
ABSTRACT:
SUBMITTER: Gispan A
PROVIDER: S-EPMC5287236 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Gispan Ariel A Carmi Miri M Barkai Naama N
Genome research 20161227 2
Eukaryotic cells initiate DNA synthesis by sequential firing of hundreds of origins. This ordered replication is described by replication profiles, which measure the DNA content within a cell population. Here, we show that replication dynamics can be deduced from replication profiles of free-cycling cells. While such profiles lack explicit temporal information, they are sensitive to fork velocity and initiation capacity through the passive replication pattern, namely the replication of origins b ...[more]