Ontology highlight
ABSTRACT:
SUBMITTER: Gitschlag BL
PROVIDER: S-EPMC5287496 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Gitschlag Bryan L BL Kirby Cait S CS Samuels David C DC Gangula Rama D RD Mallal Simon A SA Patel Maulik R MR
Cell metabolism 20160701 1
Mutant mitochondrial genomes (mtDNA) can be viewed as selfish genetic elements that persist in a state of heteroplasmy despite having potentially deleterious metabolic consequences. We sought to study regulation of selfish mtDNA dynamics. We establish that the large 3.1-kb deletion-bearing mtDNA variant uaDf5 is a selfish genome in Caenorhabditis elegans. Next, we show that uaDf5 mutant mtDNA replicates in addition to, not at the expense of, wild-type mtDNA. These data suggest the existence of a ...[more]