Ontology highlight
ABSTRACT:
SUBMITTER: Rogina B
PROVIDER: S-EPMC528752 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Rogina Blanka B Helfand Stephen L SL
Proceedings of the National Academy of Sciences of the United States of America 20041101 45
Calorie restriction can extend life span in a variety of species including mammals, flies, nematodes, and yeast. Despite the importance of this nearly universal effect, little is understood about the molecular mechanisms that mediate the life-span-extending effect of calorie restriction in metazoans. Sir2 is known to be involved in life span determination and calorie restriction in yeast mother cells. In nematodes increased Sir2 can extend life span, but a direct link to calorie restriction has ...[more]